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Reduced or dysregulated progesterone signalingas may occur with anovulation and luteal phase defects in PCOScould therefore remove an important brake on neutrophil activation, facilitating heightened oxidative responses and tissue-level inflammation [43]

Nrf2 pathway is a major target for sulforaphane

In ENS, neurotransmitters nitric oxide (NO) and vasoactive intestinal peptide (VIP) are considered to play important roles in the maintenance and protection of neurons (Sandgren et al., 2003)

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