Rushing escalation when symptoms are still present risks a step backward
Gudbergsen H, Overgaard A, Henriksen M, Waehrens EE, Bliddal H, Christensen R, Nielsen SM, Boesen M, Knop FK, Astrup A, Rasmussen MU, Bartholdy C, Daugaard CL, Ellegaard K, Heitmann BL, Bartels EM, Danneskiold-Samsoe B, Kristensen LE (2021) Liraglutide after diet-induced weight loss for pain and weight control in knee osteoarthritis: a randomized controlled trial
The out-of-pocket costs of GLP-1s have significantly lowered as of late, and this year, cheaper generic versions of semaglutide are launching in both Canada and India (unfortunately, Americans will have to wait until 2032 for the same)
Therefore, we think the preservation of TCF7L2 level in the arterial cells would be very important for the prevention and/or protection of atherosclerosis