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However, the effect of DEG treatment on these modifications differed over time, with 24 h DEG treatment required for substantive changes on lipoylation, although PDHc-E2 glutarylation was observed at 6 h (Extended Data Fig

An asymmetric lesion is more suspicious

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Lastly, even though we provided dietary and exercise counseling to all participants, energy intake and physical activity were not measured, which may be a confounding factor of interindividual variability in weight loss between groups