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The T370A substitution has no significant effect on DAMGO-induced MOR internalization while it inhibits endocytosis triggered by PKC activation (Illing et al., 2014)

But the data is lacking, and it's not clear whether the timing of supplements makes much difference

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Importantly, IGFR was reported to be expressed in the male reproductive tract including localization in early spermatids, secondary spermatids, Sertoli cells, and to a lesser extent Leydig cells (90, 91)