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The inhaled silica particles can be directly phagocytosed by alveolar macrophages (AMs), and thereby triggers NLRP3 inflammasome activation and IL-1 production, which results in a cascade release of proinflammatory and profibrotic cytokines, i.e., IL-6, tumor necrosis factor (TNF-) and TGF-1

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We observed no significant changes in the expression of p53 or p21 in keloid lesions or fibroblasts compared to those in normal skin

Furthermore, TBHP can promote the accumulation of iron ions and induce ferroptosis by inhibiting the expression and nuclear export of the FPN