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Building on the essential role of SLC25A45 in TML transport, the authors explored the structural basis for its mechanistic function

Chromatographical separation of metabolites was performed on Syncronis HILIC UHPLC column (2.1 mm 100 mm 1.7 m, Thermo Fisher) at the flow rate of 600 L/min using a binary solvent system: solvent A, 20 mM ammonium formate, pH 3.0 in mass spectrometry grade H 2 0, and solvent B, mass spectrometry grade acetonitrile with 0.1% formic acid (%v/v)

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Supplies Needed Plan based on an 816 week protocol using standard 500 IU 3 times weekly dosing