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Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes

Someone with high baseline insulin resistance may experience faster blood-sugar stabilization and early appetite suppression, while others require 68 weeks to see marked changes

Results from the TRIUMPH-4 trial, published in December 2025, showed participants with obesity and knee osteoarthritis taking retatrutide 12mg lost an average of 28.7% of their body weight at 68 weeks

Rev Colgio Bras Cir 40:191195 [DOI] [PubMed] [Google Scholar] 35.Rye P et al (2018) Efficacy of high-dose liraglutide as an adjunct for weight loss in patients with prior bariatric surgery