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The mechanism is under investigation but likely related to glucagon receptor activation
Source: West, S et al Weight regain after cessation of medication for weight management: systematic review and meta-analysis, BMJ January, 2026 Newer incretin mimetics are the GLP-1 medications semaglutide and tirzepatide
The activation of an intracellular cascade of biochemical reactions results in the phosphorylation of zona occludens (ZO) protein and myosin, as well as actin polymerization
Although the effectiveness of these treatments is stirring excitement, current roadblocks to greater use include their expense and whether they are covered by healthcare insurance providers
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