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Reduction of metabolic systemic inflammation could explain the reduction of CV events beyond glycaemic control with GLP-1 RA therapy

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Restoration of the HPG axis through weight loss addresses these symptoms at the hormonal root rather than through symptomatic treatment

Manic episodes are defined by at least 1 week of persistently elevated, expansive, or irritable mood accompanied by increased activity or energy, whereas hypomanic episodes present similar features without marked functional impairment or hospitalization