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Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells

It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number

This means it's harder to absorb than the heme iron found in meat, fish and eggs. (Incidentally, while plants only offer nonheme iron, animal foods offer both heme and nonheme.) For example, a vegetarian woman between the ages of 19 and 51 should aim for about 32 mg of iron per day