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She was on a DMARD and a biologic both at full doses and still having multiple flares per month

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Gastroenterology 132, 21312157, doi: 10.1053/j.gastro.2007.03.054 (2007)

Even among those that don't report significant clinical side effects, the financial burden of these drugs, as well as the injectable nature of the most popular versions (which much be administered via subcutaneous injection), are major deterrents for many patients