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Keratinocytes produce structural proteins, natural moisturizing factors (NMF), and barrier lipids, thereby maintaining epidermal integrity and hydration [12]

While these features are associated with a LoF phenotype, other studies suggest that both GIPR agonists and antagonists may provide benefits to T2D and obesity (Yang et al., 2022), indicating a complex mechanism of GIPR action within the processes of blood glucose and weight regulation

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