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Nat Commun (2015) 6:7715.10.1038/ncomms8715 172 DuferMHorthKWagnerRSchittenhelmBProwaldSWagnerTFet alBile acids acutely stimulate insulin secretion of mouse beta-cells via farnesoid X receptor activation and K(ATP) channel inhibition

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The historical tendency to equate pleiotropy with risk rather than opportunity appears increasingly outdated in light of contemporary successes with multi-agonist and network-based therapies

You could also experience a drop in drug levels, which may reduce the effectiveness of the patch