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In addition to the well-established benefits of CR, multiple studies have demonstrated that during intermittent fasting (IF), neurons undergo an adaptive response mediated by elevated BDNF levels, which enhance neuronal resilience and plasticity in response to metabolic stress 40,41,42

RESULTS Patients A total of 21 patients from 17 families were diagnosed with clEDS in our service and 1 patient was diagnosed abroad

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Each component targets distinct mechanisms providing researchers with a comprehensive, multi-pathway toolkit for studying anti-aging biology