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These defective mitochondria have low concentration and abnormal cardiolipin distribution in the mitochondrial electron transport chain (mETC), which cause defects in complex I formation, impairing the stability and creation of mitochondria supercomplexes (essential for normal ATP production and low mitochondrial ROS emission (see scheme in Figure 2

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1 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 2001)

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