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There is large inter-person variability in response to GLP1 medications both in terms of weight loss and side effects, with the two potentially being related (that is, people who experience more nausea may lose more weight 30 )

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Glucagon-like peptide-1 receptor agonists, or GLP-1 agonists , are a class of drugs that started as a diabetes treatment and then evolved into a popular weight loss tool

Retatrutide adds a third arm the glucagon receptor associated with raised energy expenditure rather than appetite suppression alone