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The rise of the ATP:ADP ratio in the cytoplasm closes the plasmalemmal ATP-sensitive potassium channel (K ATP ), resulting in depolarisation of the plasma membrane, which triggers the opening of the voltage-gated Ca 2+ channel [5]

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In future studies, we will further supplement this finding

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Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog

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