diarrhea with tirzepatide on (Mounjaro) affects approximately 23–31% of patients and is typically mild to moderate, transient, and most common during dose escalation. , It rarely requires discontinuation Why Does Tirzepatide Cause Diarrhea

GLP-1 is a hormone that your gut makes after you eat a meal

Immediate medical attention is warranted for symptoms suggesting serious complications: signs of pancreatitis (severe upper abdominal pain radiating to the back, nausea, vomiting), symptoms of kidney problems (significant changes in urination, swelling in legs or feet), irregular heartbeat or chest pain (which could indicate electrolyte imbalances), or signs of severe dehydration (confusion, rapid heartbeat, fainting)

But with data, you can make smart adjustments before small issues compound into stalled progress or uncomfortable side effects that make you want to quit completely

Many patients may begin to notice some weight loss within the first few weeks of starting Ozempic, with more noticeable results typically observed after 12 to 16 weeks of consistent use