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Extracellular matrix remodeling: pre-clinical models examine collagen organization, fibroblast activity, and tendon/ligament matrix response during repair-phase research

It is also involved in the formation of red blood cells and helps to create and regulate DNA

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In addition, since 4-HNE inhibits nuclear function of -catenin, which is a key factor for transcriptions required for the expression of oncogenes such as c-MYC and cyclin D1 and other genes involving in tumour initiation and progression [123, 124]