Dosis excesivamente altas durante el embarazo pueden tener efectos negativos en el feto y en el desarrollo postnatal
Although not documented in Keshan disease, it is possible that selenium deficiency may increase the virulence of viruses with the potential to invade and damage the heart muscle (57)
A recent study revealed that with increasing age, oocyte senescence leads to the downregulation of all the cellular pathways involved in NAD+ synthesis (kynurenine pathway, Preiss-Handler pathway, and NAD+ rescue pathway) and profoundly affects the activity of NAD+-dependent enzymes, i.e., PARPs and SIRTs, with further implications for many cellular functions, including impaired ROS detoxification [83]
Skinner HD, Sandulache VC, Ow TJ, Meyn RE, Yordy JS, Beadle BM, et al