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Alterations in brain network functional connectivity, particularly within networks involving the amygdala and the insular cortex, seem to play a role of brain dysexcitability in CVS patients ( Endocannabinoid System Dysfunction The cannabinoid receptor (CB) 1 and 2, their ligands N-arachidonoylethanolamine (anandamide) and 2- arachidonoylglycerol (2-AG), and their biosynthetic and degradative enzymes are the major components of the endocannabinoid system (ECS) (58)

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CIs, depending on the fruit, can lead to internal (IB) and external browning, mealiness, pitting and other manifestations of tissue necrosis (Pott et al., 2020b)