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Dihexa, as an active substance, may be sensitive to these environmental factors and prone to degradation or deterioration

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In PD, mitochondrial toxins like MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and rotenone induce oxidative stress and calcium overload, while -synuclein (-syn) accumulates at mitochondria and induces mPTP opening [52]

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