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10.1016/j.ijcard.2012.09.204

The 12 mg arm showed mean weight reduction of 16.8% at 40 weeks, with no weight-loss plateau emerging through 40 weeks

Moreover, GIP has been found to boost glucose uptake by improving insulin sensitivity in adipocytes (176, 177), while tirzepatide has been demonstrated to enhance insulin sensitivity and promote glucose disposal in white adipose tissue in Glp-1r-null mice (178), further supporting a direct effect of GIP on adipose tissues