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Many of the changes in lipid profiles related to obesity overlap with diabetic dyslipidemia including increased triglycerides, increased very-low-density lipoprotein (VLDL), increased small density LDL-C, and decreased HDL-C [18]

Theyre addressing the broader metabolic dysfunction that underlies both obesity and many cases of depression

But when you combine glucagon receptor agonism with strong GLP-1 and GIP activity, something interesting happens: GLP-1 and GIP's insulin-stimulating effects offset glucagon's glucose-raising tendency, and what's left is glucagon's other effects increased hepatic energy expenditure, upregulated fatty-acid oxidation, and thermogenesis

Long- a cting f ormulations GLP-1 RAs can be categorized into two main types: short-acting and long-acting