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doi:10.2337/dc11-1582

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and G protein signaling The is directly linked to the activation of adenylyl cyclase (AC) that leads to the production of cAMPs and downstream signal, From an assumption that the G protein signaling ( S ) above the basal level is proportional to the cellular level of cAMP [14, 58, 59], the intensity of signaling is given by More detailed expression of S for further quantitative analysis is derived and discussed below