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Why cold storage matters: peptide bonds in solution are susceptible to hydrolysis, and aggregation (where peptide chains clump together, losing receptor-binding activity) accelerates at room temperature

2.2 Exosome signaling in DKD Exosomesfirst characterized in 1982are membrane-bound extracellular vesicles that have emerged as pivotal mediators of intercellular communication and key contributors to disease pathogenesis

found that another amino acid transporter, SLC25A22, could promote Asp synthesis, activate the AMPK pathway and reduce oxidative stress in KRAS mutant colorectal cancer (CRC) cells (Fig