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Polymorphs tend to convert spontaneously from less stable to more stable forms, and, therefore, it is best to discover and characterize the stable form as early as possible Thus, any new formulations of niclosamide that are sought for testing in cells, animals, and especially in humans, and that are expected to deliver niclosamide, need to take into account the ultimate solubility of any more stable, in this case, monohydrate forms (2)
Minamimoto R, Hotta M, Ishikane M, Inagaki T
Avoid repeated freezethaw cycles as they degrade peptides over time [11]
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