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New yellowing of the skin or eyes, dark urine, or severe right upper abdominal pain also needs prompt review

doi: 10.1038/nm.4106 Summary Keywords ferroptosis, gut microbiota, iron, iron homeostasis, lipid peroxidation Citation Shi Z, Zhang S, Zhai H, Wu Q, Li Y, Xu H and Zhang S (2026) The interplay mechanisms between gut microbiota and ferroptosis in inflammatory bowel disease

The consistency of findings across different trial phases and patient populations strengthens the scientific consensus regarding its substantial efficacy in inducing weight loss

But other early research suggests that semaglutide and other GLP-1 medications could interact with the brains reward system in a way that helps modulate cravings, whether for food, nicotine, alcohol or other drugs