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Description

New Phytol 181(1):103114

Adding GIP (the tirzepatide model) deepens the effect and, somewhat counterintuitively, appears to improve gastrointestinal tolerability relative to GLP-1 alone

Further investigations are needed to determine the value of H3K27me3 as a predictive marker for establishing sensitivity to epigenetic-based therapies (EZH2 inhibitors, BRD4 targeted therapies) in tumors such as malignant peripheral nerve sheath tumor and melanoma