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DMT1, a member of solute carrier family 11 member 2 (SLC11A2), plays a role in iron transport, and its expression would be increased if exposed to high-iron environment

Kinetic analyses revealed competitive inhibition with respect to both substrates

On the basis of its clinical features, four forms of breast cancer have been identified: ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC), inflammatory breast cancer (IBC), and metastatic breast cancer

As Anpep also prevents cellular toxicity from Cys-Gly dipeptide accumulation in addition to promoting cysteine and glycine recovery, we next measured urinary Anpep levels using LC-MS in MRM mode (Figure 3C, peptide determination results are shown in Supplementary Tables S9)